Research Areas

MR Spectroscopy: Development coordination and co-development of jMRUI

MR Spectroscopy: Development coordination and co-development of jMRUI

jMRUI is a software suite for exploration and advanced time-domain analysis of magnetic resonance spectroscopy (MRS) and spectroscopic imagi…

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Perfusion MRI: AI methods for DCE-(DSC-)MRI

Perfusion MRI: AI methods for DCE-(DSC-)MRI

Quantitative analysis of perfusion MRI traditionally relies on model fitting, which is often computationally demanding and ill-posed, leadin…

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Perfusion MRI: Blind-deconvolution AIF estimation

Perfusion MRI: Blind-deconvolution AIF estimation

The accuracy of perfusion-parameter estimation in DCE- and DSC-MRI perfusion imaging depends primarily on the Arterial Input Function (AIF),…

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Perfusion MRI: Development of PerfLab

Perfusion MRI: Development of PerfLab

We have been developing online software for perfusion analysis, PerfLab. It provides standard perfusion analysis methods of DCE-MRI data and…

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Perfusion MRI: Quantification of blood-brain-barrier permeability

Perfusion MRI: Quantification of blood-brain-barrier permeability

Our research focuses on developing and validating advanced MRI-based methods for quantifying blood–brain barrier (BBB) permeability with hig…

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Perfusion MRI: Self-gated cardiac FAIR-ASL

Perfusion MRI: Self-gated cardiac FAIR-ASL

Based on our self-gated T1 quantification method [1], we derived a method for quantifying myocardial perfusion. The method uses the principl…

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Perfusion MRI: Simultaneous DCE-DSC-MRI

Perfusion MRI: Simultaneous DCE-DSC-MRI

Simultanous acquisition and quantification of DCE-MRI and DSC-MRIA combination of DCE- and DSC-MRI may be a way to enhance the diagnostic va…

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Perfusion MRI: Spatially regularized estimation of perfusion maps

Perfusion MRI: Spatially regularized estimation of perfusion maps

We have been developing new methods for DCE-MRI perfusion analysis that take the spatial context into account to improve the accuracy of per…

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T1 relaxometry: self-gated quantification in the rat’s myocardium

T1 relaxometry: self-gated quantification in the rat’s myocardium

Imaging myocardium is difficult let alone obtaining quantitative parameters. We developed fast self-gated acquisition based on inversion rec…

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Projects

Support for "Proof-of-Concept" activities at the Institute of Scientific Instruments of the CAS, v. v. i.

Support for "Proof-of-Concept" activities at the Institute of Scientific Instruments of the CAS, v. v. i.

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The goal of the presented project is, in addition to expansion of the existing system of transfer of new R&D knowledge, strengthening re…

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Modernization of Czech-BioImaging research infrastructure

Modernization of Czech-BioImaging research infrastructure

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Project goalsThe aim of the project is effective, coordinated and transparent quality assurance and further development of services provided…

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PerfLab

PerfLab

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The main goal of this project is to make PerfLab accessible to a broader professional community, subject it to testing and validation, and s…

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National Infrastructure for Biological and Medical Imaging

National Infrastructure for Biological and Medical Imaging

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The aim of Czech-BioImaging is to continue to develop a harmonized national network that coordinates the development of biomedical imaging,…

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Multi-Contrast Quantification of Perfusion Using Joint Magnetic Resonance Contrast-Enhanced and Arterial-Spin-Labeling Approaches

Multi-Contrast Quantification of Perfusion Using Joint Magnetic Resonance Contrast-Enhanced and Arterial-Spin-Labeling Approaches

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Magnetic resonance (MR) perfusion imaging is used for diagnostics and therapy monitoring mostly in oncology, neurology and cardiology, provi…

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Biodistribution and real-time monitoring of free or apoferritin-encapsulated charged cholinesterase reactivators

Biodistribution and real-time monitoring of free or apoferritin-encapsulated charged cholinesterase reactivators

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Oxime cholinesterase reactivators are used for life endangering intoxications caused by organophosphate agents. However, clinically used (so…

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Modernization of the National Infrastructure for Biological and Medical Imaging Czech-BioImaging

Modernization of the National Infrastructure for Biological and Medical Imaging Czech-BioImaging

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The aim of the project is effective, coordinated and transparent quality assurance and further development of services provided by Czech-Bio…

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National Infrastructure for Biological and Medical Imaging Czech-BioImaging

National Infrastructure for Biological and Medical Imaging Czech-BioImaging

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The aim of Czech-BioImaging is to further develop a harmonized national network that coordinates the development of biomedical imaging, rais…

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INSPIRE-MED INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine

INSPIRE-MED INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine

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INSPiRE-MED will provide research and training to 15 early career researchers in the field of medical imaging, specifically Magnetic Resonan…

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Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging

Modernization and support of research activities of the national infrastructure for biological and medical imaging Czech-BioImaging

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The aim of the project is to modernize and support the research activities of the national infrastructure for biological and medical imaging…

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Nanoliposomal systems for rapid diagnosis of thrombi by MRI

Nanoliposomal systems for rapid diagnosis of thrombi by MRI

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The research aim of the multidisciplinary project is to develop advanced nanoparticle systems for rapid imaging of thrombi in the cardiovasc…

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Magnetic resonance perfusion imaging using compressed sensing

Magnetic resonance perfusion imaging using compressed sensing

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Perfusion analysis is an important experimental technique used for diagnostics and evaluation of therapy response. Analysis based on magneti…

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TRANSACT – Transforming Magnetic Resonance Spectroscopy into a Clinical Tool

TRANSACT – Transforming Magnetic Resonance Spectroscopy into a Clinical Tool

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In vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging (MRS(I)) are unique, indispensable techniques for non-invasive metabolic i…

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Perfusion Analysis Using MRI and Ultrasound

Perfusion Analysis Using MRI and Ultrasound

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Perfusion analysis is an experimental imaging technique used for diagnostics and evaluation of therapy response in oncological and cardiovas…

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FAST, Advanced Signal-Processing for Ultra-Fast Magnetic Resonance, and Training

FAST, Advanced Signal-Processing for Ultra-Fast Magnetic Resonance, and Training

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Magnetic Resonance Spectroscopic Imaging - MRSI - is an emerging, non-invasive modality of Molecular Imaging that opens the way to in vivo m…

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