Perfusion MRI: Quantification of blood-brain-barrier permeability

Our research focuses on developing and validating advanced MRI-based methods for quantifying blood–brain barrier (BBB) permeability with high accuracy and precision. As we are equipped with a MR-guided focused ultrasound (MRgFUS), we can perform controlled and reversible BBB opening experiments. This unique capability allows us to mimic pathological BBB disruption—as seen in brain tumors and other neurological conditions—in a fully controlled setting, and also provides a powerful platform for targeted drug delivery studies.

We place strong emphasis on methodological development and quantitative imaging, ensuring that permeability measurements are both robust and reproducible. This work has led to a comprehensive investigation of the underlying modeling and analysis approaches, culminating in a peer-reviewed publication that consolidates our findings. [1]